@article{83786,
  keywords = {Humans, Tumor Cells, Cultured, Calcium, Neoplasm Proteins, Neoplasm Invasiveness, Cell Adhesion, Up-Regulation, Cadherins, Dexamethasone, Antineoplastic Agents, Hormonal, Fibrosarcoma, Proteoglycans, Laminin, Collagen, Drug Combinations},
  author = {Foty and Corbett and Schwarzbauer and Steinberg},
  title = {Dexamethasone up-regulates cadherin expression and cohesion of HT-1080 human fibrosarcoma cells.},
  abstract = {<p>The synthetic glucocorticoid dexamethasone markedly decreases the invasiveness of HT-1080 human fibrosarcoma cells. We show here that dexamethasone treatment of HT-1080 cell aggregates more than doubles their cohesivity from 3.9 to 9.7 dyne/cm. Western blot analysis shows a corresponding increase in cadherin expression. This was accompanied by an increase in the rate of calcium-dependent aggregation. Dexamethasone-treated aggregates spread to form a monolayer in Matrigel spreading assays, but the cells remained much more contiguous than their untreated counterparts. Invasion-suppression by dexamethasone may therefore be due, at least in part, to a previously unsuspected increase in cadherin-mediated cohesion.</p>
},
  year = {1998},
  journal = {Cancer Res},
  volume = {58},
  pages = {3586-9},
  month = {08/1998},
  issn = {0008-5472},
  language = {eng},
}