@article{83701,
  keywords = {Animals, Protein Conformation, Humans, signal transduction, Protein Binding, Ligands, Cell Membrane, Cytoplasm, Actin Cytoskeleton, Integrins, Talin},
  author = {Erin Cram and Jean Schwarzbauer},
  title = {The talin wags the dog: new insights into integrin activation.},
  abstract = {<p>Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.</p>
},
  year = {2004},
  journal = {Trends Cell Biol},
  volume = {14},
  pages = {55-7},
  month = {02/2004},
  issn = {0962-8924},
  language = {eng},
}