@article{202326,
  keywords = {Assembly, Extracellular Matrix, Fibrillogenesis, Fibronectin},
  author = {Yu Sun and Aaron Hamlin and Jean Schwarzbauer},
  title = {Fibronectin matrix assembly at a glance.},
  abstract = {<p>The organization and mechanics of extracellular matrix (ECM) protein polymers determine tissue structure and function. Secreted ECM components are assembled into polymers via a cell-mediated process. The specific mechanisms that cells use for assembly are crucial for generating tissue-appropriate matrices. Fibronectin (FN) is a ubiquitous and abundant ECM protein that is assembled into a fibrillar matrix by a receptor-mediated process, and the FN matrix provides a foundation for incorporation of many other proteins into the ECM. In this Cell Science at a Glance article and the accompanying poster, we describe the domain organization of FN and the events that initiate and propagate a stable insoluble network of FN fibrils. We also discuss intracellular pathways that regulate FN assembly and the impact of changes in assembly on disease progression.</p>},
  year = {2025},
  journal = {Journal of cell science},
  volume = {138},
  month = {03/2025},
  issn = {1477-9137},
  doi = {10.1242/jcs.263834},
  language = {eng},
}