@article{202276,
  author = {R Patel and E Odermatt and J Schwarzbauer and R Hynes},
  title = {Organization of the fibronectin gene provides evidence for exon shuffling during evolution.},
  abstract = {<p>We report the organization of the two ends of the rat fibronectin gene which encode the type I and II repeating units of the protein. We show that each of these modular structural units is encoded by a separate exon. Homologous type I and II repeats are known to occur in tissue plasminogen activator, factor XII and a bovine seminal plasma protein. Comparison of these sequences and the exon structures of the fibronectin and tissue plasminogen activator genes indicates that exons encoding type I and type II repeats have reassorted during evolution. We also report analyses of the extreme 5{\textquoteright} and 3{\textquoteright} ends of the fibronectin gene including the promoter region and the exon encoding the prepro sequence of fibronectin and we show that the gene is transcribed from a single initiation site to a single polyadenylation site. These data provide information pertinent to the transcriptional regulation of the gene, the alternative splicing of the primary transcript and the structure of the primary translation product.</p>
},
  year = {1987},
  journal = {The EMBO journal},
  volume = {6},
  pages = {2565-72},
  month = {09/1987},
  issn = {0261-4189},
  language = {eng},
}